Piggybacked by PEGylation?

Genetic PEGylation

Polyethylene glycol (PEG) was genetically incorporated into a polypeptide. Stop-anticodon-containing tRNAs were acylated with PEG-containing amino acids and were then translated into polypeptides corresponding to DNA sequences containing the stop codons. The molecular weights of the PEG used were 170, 500, 700, 1000, and 2000 Da, and the translation was confirmed by mass spectrometry. The PEG i...

Some Heuristics About Piggybacked Binding Updates

In this short document, we present some analytical intuition with respect to piggybacking. Piggybacking is the insertion of a binding update (BU) into a regular payload packet sent from the mobile node (MN) to the correspondent node. Attaching the BU to a packet that goes to the same destination saves the MN from sending a BU in a separate packets, and optimizes the resource. In this document, ...

PEGylation of therapeutic proteins.

Since the first PEGylated product was approved by the Food and Drug Administration in 1990, PEGylation has been widely used as a post-production modification methodology for improving biomedical efficacy and physicochemical properties of therapeutic proteins. Applicability and safety of this technology have been proven by use of various PEGylated pharmaceuticals for many years. It is expected t...

Supramolecular PEGylation of biopharmaceuticals.

The covalent modification of therapeutic biomolecules has been broadly explored, leading to a number of clinically approved modified protein drugs. These modifications are typically intended to address challenges arising in biopharmaceutical practice by promoting improved stability and shelf life of therapeutic proteins in formulation, or modifying pharmacokinetics in the body. Toward these obj...

Drug delivery: Relieving PEGylation.